Synthline® on the Web presents in structure-searchable format the schemes of synthesis for drugs currently on the market or in development worldwide. Each scheme is linked to its original reference citation(s) and to basic information for the end product synthesized. Textual descriptions of the routes of synthesis are linked to many of the schemes.

The Synthline® database covers more than 15,000 schemes of synthesis of more than 9,500 drugs currently marketed or in clinical trials worldwide and provides structure-searchable access to more than 68,000 chemical intermediates and reagents from these schemes.

Premier publications in the field of medicinal chemistry and the current patent literature. The database includes all schemes of synthesis published in the popular Prous Science journal Drugs of the Future (monographs and the Information Update section) since January 1976.

Synthline® on the Web users must have an Internet connection and a JavaScript-enabled Web browser (e.g., Netscape 4.0 or higher; Microsoft® Internet Explorer 4.0 or higher. No additional software is required to search on information in the full-text search module of Synthline® on the Web.

The chemical structure search module of Synthline® on the Web is a CS ChemOffice^TM Webserver application. To utilize the chemical structure search function, users must have installed on their computers the CS ChemDraw^TM Net Plugin that can be downloaded at no charge from CambridgeSoft Corporation (http://www.camsoft.com).

Registered users receive a User ID and Password granting acces to Synthline® on the Web

• A powerful search engine that allows text and structure search criteria to be combined from multiple fields across seven search subsystems (End Products, Synthesis Schemes, Synthesis Intermediates, Chemical Reagents, References, Patent Families, and Chemical Structures).
• Total integration of chemical structure search and text search.
• Chemical Structure Search feature for use with the CS ChemDraw™ Net Plugin, which can be downloaded at no charge from CambridgeSoft Corporation.
• Advanced Chemical Structure Search features that allow searching in End Products (Drugs), Synthesis Intermediates, and Synthesis Schemes by substructure search, exact search, or Tanimoto similarity search.
• Presentation in chemical format (*.CDX) of the structure of End Products (Drugs) and Synthesis Intermediates, allowing manipulation (display, copy, save…) with the same version of the CS ChemDraw^TM Plugin that is used to search by chemical structure.
• Automatic statistics display that facilitates data analysis, highlights trends, and filters information.
• Hyperlinked navigation across all subsystems.
• Browse Indexes of controlled vocabulary for targeted searching.
• Field Indices that provide direct links to data subsets.
• Query Manager feature for storing, editing, and reusing search strategies.
• Sort feature to sort and display search results in ascending or descending order by a wide choice of fields.
• Checklist option to bookmark record subsets for display, printing, or statistical analysis.
• Options to display and print information in several formats (record list, basic record, full record).