Dr. Feldman, Dr. Rydén, I truly appreciate the opportunity to share some thoughts with you today, and would like to open with a quote from Dickens' Tale of Two Cities: "It was the best of times and it was the worst of times"... and so it was in the 20^th century and so it will be in the 21^st century, and so it is with the situation of heart failure. It's the best of times in the sense that we have learned a tremendous amount regarding the pathophysiology of heart failure; it's the best of times in that we have a tremendous number of effective compounds to treat these patients, it's the best of times in the sense that we have exciting new drugs down the road that we will be using. But it is the worst of times because we do not have good clarification sometimes of how best to use these compounds.