Welcome To SMR symposium New Horizons in Drug Metabolism, Pharmacokinetics and Drug Discovery webcast


	Successful introduction of a new drug to the market is not only an extremely costly and complicated process, but also fraught with a substantial risk of failure. The statistics for new introductions over the period 1990 to 2000 show a relatively constant number of between 30 and 50 per year, while the cost of pharmaceutical R&D has risen by almost 2.5 fold, from $20 billion to $47 billion over the same period. What is not revealed by these figures is that the chance of success for a drug candidate passing through the various hurdles in pharmaceutical development is at best one in 10, and has barely changed despite advancing technology in other areas of R & D. While we expect high failure rates in drug discovery, it is of substantial concern that most candidates in development, on which large investments have already been made, are probably not going to make any return. A major stumbling block is the DMPK profile of drug candidates. The science of DMPK applied to the process of drug discovery has undergone a revolution in recent years. In response to the need to assess DMPK-related parameters earlier in the drug discovery process, a fresh approach has arisen, with the introduction of new instrumentation and techniques. This SMR webcast considers the contribution of DMPK to drug discovery, with an overview of current progress and challenges in silico, in vitro, and in vivo (in both experimental animals and humans), together with consideration of the increasing contribution of bioanalysis and pharmacogenomics. With best wishes and kind regards Alan M. Palmer Honorary Secretary and Meeting Organiser http://www.socmr.org
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